In accordance with this observation, Sunshine et al. assumed that there could be two different cells of origin for the two subtypes of MCC (119). They provided several arguments in favour of this conclusion. For example, while the UV mutation nature of viral MCC nene promotes epidermal origin, the failure of the epidermis-targeted TA expression indicates that tumors resembling human MCC indicate, in mouse models (68, 120, 121), that other skin cells, such as the painter Fibroblast, can serve as the origin of MCC (119). Because UV-induced MCC and the virus occur in sun-exposed areas, In cases where frequently UV-induced mutations are observed in keratinocytes (122), but where only negative CASEs of MCPyV are characterized by high exposure to the mutation and UV signature (22, 119), Sunshine and colleagues excluded epithelium and suggested a fibroblastic origin of MCC (119). However, a low mutation load and a missing UV signature in MCC MCC could also be explained by the integration of mcPyV into a hair follicle cell that, like malral fibroblasts, is found deeper in the skin than normal epidermal keratinocytes. 72. Fradette J, Godbout MJ, Michel M, Germain L. Location of Merkel cells on areas of hairless and hairless human skin with keratin 18. Biochem Cell Biol.

(1995) 73:635-9. doi: 10.1139/o95-070 Editor and review members are the latest on their loop profiles and should not reflect their situation at the time of verification. 98. Akiyama M, Dale BA, Sun TT, Holbrook KA. Characterization of hair follicles in human fetal skin: Human fetal curvature is a pool of undifferentiated keratinocytes. J Invest Dermatol. (1995) 105:844-50. doi: 10.1111/1523-1747.ep12326649 Quote: Kervarrec T, Samimi M, Guyétant S, Sarma B, Chéret J, Blanchard E, Berthon P, Schrama D, Houben R and Touzé A (2019) Histogenese von Merkel Cell Carcinoma: A Comprehensive Review.

Up front. Oncol. 9:451. doi: 10.3389/fonc.2019.00451 . . . . 61. Su LD, Fullen DR, Lowe L, Uherova P, Schnitzer B, Valdez R. CD117 (KIT receptor) Expression in Merkel cell carcinoma.